Should Chemotherapeutic agents (ChAs), because of their antimicrobial effect, be considered an integral part of current treatment protocols for peri-implantitis? This study 1, investigated whether ChAs residues alter titanium physicochemistry and thus compromise cellular response to decontaminated surfaces..
The study concluded:
ChA-specific residues left on the titanium surfaces altered titanium physical properties and adversely affected the osteoblastic response irrespective of their observed antimicrobial effect. Chlorhexidine may compromise the biocompatibility of titanium surfaces, and its use is not recommended to detoxify implants. Sterile saline, citric acid, and NaOCl-EDTA may be proposed for use in the treatment of peri-implantitis. Contrary to previous studies that recommended the selection of ChAs for the decontamination of titanium implants according to their antimicrobial effects, the present study demonstrated that the restoration of the biocompatibility of contaminated titanium surfaces is also contingent on the preservation of titanium material properties.
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1.J Periodontol. 2016 Jun;87(6):619-29.Antimicrobial Agents Used in the Treatment of Peri-Implantitis Alter the Physicochemistry and Cytocompatibility of Titanium Surfaces.. Kotsakis GA et al.