PRF vs. PRP: Which is preferable?

I have heard about the benefits of using PRP [platelet rich plasma] and PRF [platelet rich fibrin] but I am not clear on exactly how these can improve the healing process of bone grafts and what the differences are between the two protocols. I understand there is some controversy of which stimulates osteogenesis and soft tissue growth. Which method is preferable? Can these be used with an alloplast?

Key Differences between PRP and PRF

Throughout the years, there have been several different techniques proposed for drawing a patient’s own blood to obtain beneficial platelet concentrates. The two more popular methods are known as platelet rich plasma (PRP) and platelet rich fibrin (PRF), which is the newer, and quite frankly, simpler, technique.

Without getting too technical, PRP is done by adding anticoagulant to the drawn blood and then spinning that in a centrifuge. After this initial spin, the material is aspirated and put in another tube without anticoagulant, and spun again in a centrifuge, which provides 3 layers of platelets. Finally, cPRP (concentrated platelet rich plasma), is obtained from the tube and mixed again with bovine thrombin and calcium chloride prior to application.

As opposed to PRP, PRF is extremely simple. There are no anticoagulants, no need for thrombin additives, and no need for a 2-spin centrifugation. The simple protocol for PRF is just this: “A blood sample is taken without anticoagulant in 10-ml tube which is immediately centrifuged.” The interaction of the blood with the silica in the glass tubes starts a process of natural polymerization, and fibrin clot can be obtained in the middle of the tube following the spin. The success of the PRF process “entirely depends on the speed of blood collection and transfer to the centrifuge. Quick handling is the only way to obtain a clinically usable PRF clot.” There are different guidelines as to the spin cycle required for PRF creation, though recently new centrifuges have been developed with one-push buttons for specific spin cycles. Interestingly, because PRF is performed according to a completely natural process, without any modifiers, it is not considered a blood-derived product. It is in essence similar to any totally autologous material prepared extemporaneously, like a bone harvest (chin) or palatal connective tissue harvest. This fact alone has important implications for the choice of PRF over PRP, especially in dental settings.

References:

  1. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Mar; 101(3):e37-44.
  2. Prakash S, Thakur A. Platelet concentrates: Past, present and future. J Maxillofac Oral Surg 2011;10:45-9. Back to cited text no. 3
  3. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. Safety Issues Associated With Platelet-Rich Fibrin Method

56 Comments on PRF vs. PRP: Which is preferable?

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CRS
3/30/2013
I stopped using PRP due to the expense of the kits, I works fine for sinus lifts but I have seen literature that it is better for soft tissue, it can also be combined with BMP-Rh2 but there are studies that large doses of BMP have been linked to cancer. I use prgf which is the BTI product. It works very well and is cost effective. I don't know about PRF, I just know that simply spinning down a blood clot without paying attention to how the platelets and growth factors are released doesn't really help healing. I think one has to do their own research when selecting a product there are so many products and claims out there in the dental market. I usually get my information from the better contuing Ed implant courses as to what products are recommended. Good luck.
IE DDS
4/2/2013
I used PRP for 8 yrs but the past 2 yrs have switched over to PRF. The PRF is easier to work with. I can make membranes with it. I use it for osseus grafts, perio grafts, sinus lift procedures, extraction sockets. I have not used PRFG. The PRF has a slower release of the platelets compared to PRP and a higher concentration of leucocytes. No problem using with an alloplast grafting material.
Bruno Nicoletti
11/20/2013
A well known PRP device is very cheap but sundries its black gold prices I can only say Medifuge c.g.f , vacuette tubes are about $2 each Readily available from the Medifuge supplier or from most medical suppliers brand Bio_one made in Austria You should use only 23 gauge needle which is the best size to allow free plasma flow in USA unit is available..... ???, contact Silfradent Italy
Sameh Barsoum
3/31/2013
I use PRF in almost every graft procedure I do. You may want to watch this compiled video of a case at graft stage and at implant placement http://www.youtube.com/watch?v=FjOR3bbjM8c
Dr. Smith
4/2/2013
Not evidence-based. No evidence to support use of either. I have not seen any good literature on PRF and some animal models have shown no difference. The same holds true for PRP.
Devin
12/5/2017
Dr. Joseph Choukroun and Dr. Richard Miron have written a book on this topic called "Platelet Rich Fibrin in Regenerative Dentistry: Biological Background and Clinical Indications". As far as PRF or PRP creating better bone, I am doubtful. PRP and PRF have only been shown to improve soft tissue healing
GMK
4/2/2013
The science is pretty clear: for internal medicine, the choice is PRP. For dermatology and orofacial, the best choice is PRF. Look up this paper: Current Parmaceutical Biotechnology, 2012, 13, Dohan and Al: Current Knowledge and Perspectives for the use of PRP and PRF in oral and Maxillofacial Surgery. Not even talking about cost here....
Dr shyam mahajan Aurangab
4/2/2013
For last two years , we use PRF for almost every implant case. Sure for every case of sinus agumentation/ sinus lift/ graft procedure/ immediate transitory prosthesis cases. PRF works great. Its easy to prepare in your own clinic , prepared from patient's blood without adding any chemical & is almost free. I use centrifugal machine which is very economic.( around 100 + $ ) . Sorry , I do not know how to put photographs in blog. It may help to explain better.
Robert J. Miller
4/2/2013
There is an old axiom, "You don't know what you don't know", that was never more applicable than it is for this debate. For those of you who have made the statement that there is no literature to support the use of PRF in Oral surgery/Implantology, what journals have you been reading? There are over 85 recent peer-reviewed papers for PRF that run the gamut from biology to clinical applications and I would be happy to give anyone the link to this bibleography. Dr. Dohan, et al, from France, clearly has been the best researcher in the field and has made the statement that PRF concentrates more platelets in a single pass than PRP, and that the viability and survival of platelets is clearly superior in the PRF process. So let's get off that horse with regard to research. With regard to process time, ease of protocol, handling, timing of release of growth factors, and cost, PRF clearly is the winner in every category. RJM
Ninian Peckitt
5/18/2017
PRF activates the NF-kB Pathway which counteracts bone formation. P-PRP promoted 1. HBMSCs (Human Bone Marrow Osteoblastic Stromal Cells) proliferation, viability and migration 2. EaHy926 Proliferation (transformed human umbilical vein endothelial cells) a stable source of endothelin converting enzyme (ECE) 3. EaHy926 m tube formation 4. HBMSCs osteogenic differentiation promotion (in vitro) compared with L-PRP. So P-PRP wins on bone regeneration on the evidence to date. Evidence suggests that PRF promotes soft tissue healing probably through NF-kB Pathway. This debate is fueld by commercial interests which will act as a barrier to evidence based scientific investigation. Wenjing Yin et al 2016 https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0825-9
Cliff Leachman
5/18/2017
The article is about l-PRP and P-PRP not PRF? Am I confused?
Dr shyam mahajan Aurangab
4/2/2013
Thanks Dr Robert. Giving just one article for reference. As Dr Robert said there are many,As a clinician our experience is PRF is big help in most surgeries. Volume 22 , Issue 3 May/June 2007 Pages 417–422 Platelet-Enriched Fibrin Glue and Platelet-rich Plasma in the Repair of Bone Defects Adjacent to Titanium Dental Implants Tae-Min You, DDS / Byung-Ho Choi, DDS, PhD / Shi-Jiang Zhu, MD / Jae-Hyung Jung, DDS / Seoung-Ho Lee, DDS, PhD / Jin-Young Huh, DDS / Hyun-Jung Lee, DDS / Jingxu Li, DDS PMID: 17622008 Purpose: The aim of this study was to compare the effects of platelet-enriched fibrin glue and platelet-rich plasma (PRP) on the repair of bone defects adjacent to titanium dental implants. Materials and Methods: In 6 mongrel dogs, 3 screw-shaped titanium dental implants per dog were placed into the osteotomy sites in the tibia. Before implantation, a standardized gap (2.0 mm) was created between the implant surface and the surrounding bone walls. Six gaps were left empty (control group), 6 gaps were filled with autogenous particulate bone mixed with PRP (PRP group), and 6 gaps were filled with autogenous particulate bone mixed with platelet-enriched fibrin glue (fibrin glue group). Results: After 6 weeks, the bone-implant contact was 59.7% in the fibrin glue group, 29.2% in the PRP group, and 10.2% in the control defects; this difference was statistically significant (P < .05). Discussion and Conclusion: Greater bone-implant contact was achieved with platelet-enriched fibrin glue than with PRP. The results indicate that platelet-enriched fibrin glue can induce a stronger peri-implant bone reaction than PRP in the treatment of bone defects adjacent to titanium dental implants. Int J Oral Maxillofac Implants 2007;22:417–422 Key words: bone grafting, bone regeneration, dental implants, fibrin glue, platelet-rich plasma
Cliff Leachman
4/2/2013
I would be more interested in which dentists find more preferable L-RPF or CGF?
GMK
4/2/2013
Be careful about liability when using it in the USA. There is only ONE system commercially available for L-PRF that has been FDA approved. Using just a lab centrifuge, won't do the job, and you will have a hard time defending in case of any problem linked or not to your surgery....
Dr. Suhas Vaze
4/3/2013
PRP and PRF both are not necessary. Operative site gets covered with blood clot and that is good enough for healing. Good surgical aseptic technique is all that is required for normal healing.
Dr Shyam Mahajan
4/4/2013
Dear Suhas If you say it is not necessary , do you mean to day all the study done on PRF is not correct ? Just for sake of discussion - will you say its not necessary to do implants when removabel partial dentures / bridges work . With what ever clinical experience we have PRF gives much better results as written in previous blog .
Robert J. Miller
4/3/2013
With all due respect, you are correct in your statement about "normal" healing. But what we are doing here is getting "accelerated" healing. Why should I wait for the normal healing cascade to take place when I can get, in one one week, the healing response I normally see at 3-4 weeks? We live in the era of biologics. We understand the entire wound cascade and the growth factors associated with all of the phases. Our strategy today is to give mother nature a helping hand to compress both healing and treatment time. Isn't that what prudent clinicians do? Additionally, Intra-Lock International has the only FDA cleared L-PRF system in the US. For medico-legal reasons, this system should be what you use for your procedures. RJM
GMK
4/3/2013
Robert Miller is 100% correct. If we reason as Suhas, then "Air conditioned automobile" or "cellphone" or "internet" are not needed. But who would give them up today?
Daniel P. Camm
4/3/2013
This discussion is on-going. There is a wealth of literature that supports the use of PRP-PRF. Much of it has been done by Jim Rutkowski, the editor of the Journal of Oral Implantology. It is definitely effective for bone and soft tissue formation. I use it for every bone grafting case I do and for most of the implant cases. With Dr. Rutkowski's technique, the cost is about $7 per case, and the time of acquiring both the PRP and the PRF is about 10 minutes. Everything necessary to do it is available from Salvin Dental Supplies. There is no reason NOT to use it. If you would like to talk to me about the technique, call me at 440-655-6512. I would be glad to send you a slide series showing the technique. Dr. Rutkowski and Dr. Jim Fennell are giving a two-day course in April on the use and technique of using PRP-PRF. I suggest you Google Dr. Rutkowski to read his research or to find out about the course. Dan Camm
GMK
4/3/2013
With all respect, could not find a single publication from Dr Rutkowski on PRF. Could you pls advise where to search? FOund about 100 from other authors in US and other International journals....
dmf
4/3/2013
If you search Google, you'll find what you need. Here is one article I found after doing a simple search: Journal of Oral Implantology, 2010; Vol. 36. The link to the PDF is here: http://www2.allenpress.com/pdf/ORIM36.1FNL.pdf
GMK
4/3/2013
Thanks DMF. Got the paper. It is about PRP. Also found on Google some papers featuring co-author Dr Rutkowski... The main difference between PRF and PRP are: Fibrin and Leucocytes present in PRF but not in PRP. That explains the difference in indications and clinical behaviors. ONLY PRF makes a difference on soft tissue closure. All authors agree on that. If soft tissue heal faster and better, guess what happens to the underlying bone?
Daniel P. Camm
4/4/2013
With the single-spin technique, which is very effective at concentrating platelets, I draw up two tubes of blood: One tube has sodium citrate to keep the blood from coagulating. When I spin that down, I can draw out the PRP (liquid "Buffy Coat") laver into a syringe. I mix that with bone graft, place it onto CollaPlugs, place it on sutures. How effective is it? It is free and easy, so even if it is just a little effective, it is worth it. I think it gives a real jump start to the healing process. I see a noticeable difference. The other tube I draw up has nothing in it. I spin it down immediately with the other tubes for 10 minutes. I get a separated clot of blood: plasma on the top of the clot, RBC's on the bottom of the clot, and in between the concentrated platelets "trapped" in this clot. I lay it on a slab and cut off 2/3 of the plasma and 2/3 of the RBC's. I place this clot in a socket, or I squeeze it with a Rutkowski "squished" from Tatum Instruments into a membrane and place that over a surgery site under the flap. With the PRP, it is liquid, so it probably stays in the area a short time. With the PRF, it is a clot, so the platelets open up over a period of time. The preparations are exactly the same in content. They just are a different form of concentrated platelets. Daniel Camm
Cliff Leachman
4/6/2013
Daniel what is the RCF you are using on your centrifuge? Could everybody reveal their RCF, not the RPM because that differs Depending on the centrifuge parameters. Also temperature. Being a chef, before becoming a dentist I'm inclined to try others recipes to See if I can improve the result. it is cooking!
GMK
4/4/2013
There are some "cooking recipes" with no scientific evidence to back them up, and there are controlled studies published in peer reviewed journals.... Characterization and valid protocols have been published years ago, about PRF. The best start consists in reading them, and trying them before trying to "enhance"... The most prolific author in the literature to write about PRF over the last 5 years has been Prof. Dohan. I recommend reading this classification to understand difference between various platelets concentrates: Trends Biotechnol. 2009 Mar;27(3):158-67. doi: 10.1016/j.tibtech.2008.11.009. Epub 2009 Jan 31. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Dohan Ehrenfest DM, Rasmusson L, Albrektsson T.
Daniel P. Camm
4/4/2013
Thanks for the references. I love reading the intricacies of this procedure and why it works. From a clinical perspective, I love this procedure for the following reasons: 1. At the very least, the literature suggests that it is effective. It may not be 100% proven, but it is well supported. 2. There is a start up cost for the centrifuge and materials of about $1700, but after that, the cost per procedure is almost nothing. 3. The time to do the procedure is 10 minutes. With a 2-3 hour surgery, this is inconsequential. 4. Anecdotally, I notice a distinct difference in healing time with this procedure. 5. There is absolutely no harm to the patient. Why not do this procedure? There are very few things we do in dentistry that fit all these qualities. Daniel Camm
GMK
4/5/2013
I agree 99% with Dr Camm. The 1% difference is on the procedure: let's use the already published and approved procedures before trying to "enhance the recipe".
Robert J. Miller
4/6/2013
I am throughly confused by Dr. Camm's protocol, as it is neither PRP or PRF. Platelet Rich Plasma requires a dual spin centrifuge where a large tube of blood has been treated with anticoagulant (sodium citrate) and then treated with calcium chloride to make a gel and bovine thrombin to release growth factors from the platelets. Platelet Rich Fibrin uses none of these chemical additives and, as a result, releases growth factors over a sustained period of time (7-14 days). It should never come in contact with anticoagulant. Why would you even entertain the idea of adding your "version" of PRP when all of the growth factors from both the platelets AND leucocytes are present in ideal amounts? RBC's have never been a part of the PRF protocol and are essentially useless; they should be removed completely. Finally, to get an ideal result using PRF, you should have the instrumentation to fabricate socket plugs and membranes. All of the histology and research has been done in these forms. Using an FDA cleared PRF System (Intra-Lock International) will protect you medico-legally should your case develop problems post-surgery. Caveat Emptor. RJM
Daniel P. Camm
4/6/2013
Robert: Look at my post from April 4, where I explain the technique. There are TWO separate tubes. One has sodium citrate, from which I get PRP liquid. These tubes are 5cc tubes, although 10cc ones can be used. The other tube has nothing in it. These are 10cc tubes. When spun down (in the same spin), I get PRP liquid in the sodium citrate tubes, and I get a separated clot in the other tubes which I can use as a clot mass or I can flatten into a PRF membrane. So with a quick draw of 2,4,6, etc tubes, I get to use PRP and/or PRF. The tube with no additives coagulates during the 10-minute spin process. I NEVER use bovine thrombin. The use of that opens the platelets way too fast and makes the growth factors dissipate too quickly. There is no need to use bovine thrombin. In isolating the concentrated platelets into a syringe (the "buffy coat"), it is unavoidable that some immature RBC's are also drawn up. They do not hurt the technique, and there is no need to use expensive systems to avoid them. There is no need to use huge tubes and do a double-spin technique. Dr. Rutkowski has shown that the single spin technique with a CliniSeal centrifuge produces more that adequate concentration of platelets. I reference the following article: J Oral Implantol. 2008;34(1):25-33. doi: 10.1563/1548-1336(2008)34[25:AAOARS]2.0.CO;2. Analysis of a rapid, simple, and inexpensive technique used to obtain platelet-rich plasma for use in clinical practice. Rutkowski JL, Thomas JM, Bering CL, Speicher JL, Radio NM, Smith DM, Johnson DA. Source Duquesne University, Pittsburgh, Pa., USA. Abstract The use of platelet-rich plasma (PRP) has become more generally accepted, and implant dentists are using PRP more frequently to promote the healing of oral surgical and/or periodontal wounds. Critical elements of PRP are thought to be growth factors contained within the concentrated platelets. These growth factors are known to promote soft-tissue healing, angiogenesis and osteogenesis. We present a rapid, simple, and inexpensive methodology for preparing PRP using the Cliniseal centrifuge method. This study demonstrates that platelets are concentrated approximately 6-fold without altering platelet morphology. Further we demonstrate that key growth factors, platelet-derived growth factor BB (PDGF-BB), transforming growth factor B (TGF-B1), vasculature endothelial growth factor (VEGF), and epidermal growth factor (EGF) are present in comparable or higher concentrations than those reported with the use of other techniques. Prolonged bench set time (>3 hours) after centrifugation resulted in decreased concentration of TGF-B1 but not decreased concentration of PDGF-BB, VEGF, or EGF. This study confirms the molecular aspects of PRP obtained using this inexpensive and efficient methodology. The research has been done. The technique is easy and effective and inexpensive and SAFE. You would service your patients well to learn this. To make a statement that a clinician should only use an FDA-approved system is ludicrous. Act like a doctor. Do the research and study the technique. The manufacturers are not the teachers. Daniel P. Camm
Carlos Boudet, DDS
4/6/2013
Thanks Dr. Cam for the informative article by . Dr. Rutkowski. I think research like that continues to increase the awareness and use of growth factors and tissue engineering in the daily practice of implantology.
Daniel P. Camm
4/6/2013
The RCF on my centrifuge is 1,132 x g, and I use it at room temperature. Dan Camm
cliff leachman
4/6/2013
Thanx! So very close to the 1150 X g in the Rutlowski paper, 10 minutes?
Cliff Leachman
4/6/2013
I gotta say putting the PRP mixture onto the L-RPF membrane would help keep it in place, instead of washing out and would make it a "super band-aid" . I am gonna try it on Monday, regardless of the literature, after all I live in Canada and we worry less about litigious patients, but you always have to be on the lookout.
GMK
4/6/2013
I always like the concept of "Keep It Simple": 1- L-PRF is a single spin technique. 2- No Additive in the tubes 3- Making membranes express the "juice" inside the Xpression kit. 4- This serum is used to boost biomaterial soaking in there while you perform surgery. 5- There are tons of literature about the technique. 6- FDA approved and inexpensive. Why bother about re-inventing the wheel? + Adding PRP onto the PRF membrane is a strange idea. Its relevance has to me measured in a controlled study. That has not been done as far as I know....
CHOUKROUN Joseph
4/24/2013
GMK, strange, you forgot all my articles and the principal who was the first. Xpressing is a vulgar copy of the PRF Box. May be you are a guy from the intra-lock team? It should explain the nature of your posts.
Robert J. Miller
4/6/2013
Dan; I understand that you use two tubes. But I take exception to the statement about "acting like a doctor". A part of doctoring is reading the literature and understanding it. And I have read Jim's paper as well. But here is your disconnect. The concentration of growth factors is directly proportional to the number of platelets and leucocytes present in the blood draw. There is a series of pioneering papers authored by Dohan, et al, entitled "Platelet Rich Fibrin (PRF): A second-generation platelet concentrate Parts I-IV" in Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006; where they make the statement (based on histomorphometric analysis) that close to 100% of the platelets are harvested in the PRF clot. So if I desire additional platelets, I simply use an additional membrane. But the one thing that the "PRP" of your protocol does not contain is leucocytes (since you are using only the buffy coat), one of the main reservoirs of VEGF.So it would seem that PRF is the desired protocol if your arbiter of efficacy is concentration of growth factors. One last point is that your PRP platelet mass is now contaminated with sodium citrate, which may delay local coagulation and subsequent early angiogenesis. So before you start suggesting that clinicians use a new empirical protocol, let's wait for a controlled study that directly compares both so that we can judge the effectiveness of each protocol. Now that's doctoring! RJM
Joseph CHOUKROUN
4/24/2013
Sorry Dr Miller, I do not agree with your comments for many reasons (I already posted opinions about your wrong comments related to the PRF protocol): 1. PRF does not release growth factors during 14 days. You must read carefully the articles. 2. You write that Intra-Lock is the only one company who has the FDA approval. You must be more informed about the medico-legal. Putting these comments place yourself in a very big conflict of interest as you are shareholder of Intra-Lock !!! 3. The king is dead, long live the King!! The PRF will be replaced the next week by the Advanced PRF: A-PRF. I developped this new protocol to get BMP-2 and BMP-7 with long term release. For free. It took two years of research. I changed all the settings, the tubes etc. and the A-PRF outcome in the bone grafts is more powerful. Definitely.Publications soon. Sorry for the copiers who are only able to propose material and never understand what is the biology: they are not able to give the right information and to teach as well the doctors. Joseph CHOUKROUN
Robert J. Miller
4/26/2013
The slow release of growth factors up to 7 days was published in 4 different articles, but I have just participated in an in vitro study using IntraSpin showing release up to 14 days. This is going to publication as we speak. Intra-Lock is the only company with FDA and CE marking for PRF, this is a fact and the reality of the PRF protocol. It is also a fact that Dr. Choukroun is the owner of the Process for PRF company, selling a machine without fulfilling any of the legal requirements; No CE marking and no FDA 510k clearance,. That is a major conflict of interest. Maybe in France the authorities will tolerate this or simply are not aware that there is no clearance for his machine. We have heard of the scandal of the French company PIP that sold hundreds of thousands of breast implants, only to break open after a few months/years causing untold injuries. Perhaps that is why we have stringent guidelines in this country before we can market a medical device. If you use a medical device in the US without certification, the authorities simply close your business. Are you suggesting that US dentists ignore this and open themselves up to potential legal issues? How can there be any debate on this issue? We should be thankful to Intra-Lock for doing the heavy lifting and absorbing the expense of certification while keeping the cost of the system at a reasonable price point. Compare that to the high costs of PRP and PRGF systems. I would suggest that Dr. Choukroun do the same with regard to CE and FDA clearance. After all, Process is his company and I would suggest he not engage in ad hominum attacks with his "inventive" statements. Last, your statement that "people do not understand biology" is incredible coming from you, as these studies were done by some of the best PhD's in our profession.The last time I heard this expression, it was about...you. From the mouth of the academic people and clinicians that collaborated with you in the past, particularly on PRF, and now consider you to be completely commercial. I believe that this forum is not the place for this kind of agressive messaging, Dr. Choukroun. RJM
Cliff Leachman
4/27/2013
Comparing this issue to French breast implant failure is sad and irrelevant. Medical/legal issue is poorly argued as well. I use a 400lb hospital grade Heraeus Megafuge1.0R, which is often the reference centrifuge for many membrane experiments in the literature, instead of a mini-proprietary centrifuge that becomes obsolete the moment new parameters become the standard. I would also argue that if this isn't the place for controversial discussion what plac would be? I own NO stock in any dental company, I just want to improve my surgical results by using the best platelet products possible and as they improve I want to change as well and not end up with a storage room full of antiquated centrifuges. Why don't try to produce one that you can alter the settings for future iimprovements, not a good business decision, but an excellent decision for someone looking for long term success!
Terry
4/27/2013
400lbs? Wow? How much cost your centrifuge? I'd rather spend a couple of grand only, and have a "legal" stuff. Plus, you can change the settings if you wish...
Cliff Leachman
4/27/2013
Actually I think its 460lbs, but it was refurbished for a grand total of $1200, bought for $350 at an auction. Many are out there, just try a lab equipment sales, online or otherwise. I have a second Heraeus Megafuge 1.0R in for 2nd hand parts and servicing for a dentist friend.
Richard Hughes, DDS, FAAI
4/28/2013
Drs Choukroun and Miller, would you please be so kind as to provide us with a list of manuscripts on this topic. I am sure there are many that would like to have a deeper understanding on this topic. I have always enjoyed the comments from both of you. I thank you
Robert J. Miller
4/29/2013
Richard; You can find a long list of PRF papers in the PRF module of the Intra-Lock website (intra-lock.com). I personally have a list of over 85 peer reviewed papers on the subject with several more as yet unpublished manuscripts waiting to be accepted. RJM
Joseph CHOUKROUN
5/4/2013
Dr Miller, I never cite my own company in the forums. In all of your post you cite I-L. We have the CE and we do not need FDA approval. I'll publish soon the FDA letter. I confirm here that you are not able to do PRF education. Intra-spin is the 100% copy of the PC02. You got the machines by chance. and you'll stop to get them soon. be sure.
Bruno Nicoletti
11/19/2013
Medifuge c.g.f. made Silfradent has all approvals and is a phase separator which is superior than a one speed centrifugation protocol.....
Cliff Leachman
11/20/2013
Is there actual research showing its superiority? Salesman or scientist?
Bruno Nicoletti
11/20/2013
View the web for Medifge c.g.f ... There is much research already available including GBR without additions..... unfortunately the net have been hijacked by others also that claim their powder is concentrated growth factors Medifuge C.G.F protocol is a plasma phase separator by gravitation, phase separation occurs with a series variation of rpm with controlled acceleration...... / the g forces Creates a Liquefied ( a protocol PRP ) and/or Fibrin block matrix without additives Liquefied you can view the various layers PPP - PRP - CGF - RBC Fibrin block matrix is of high tensile elastic strength, ...... ideal for a quality autologous membrane ...... A PRP device has dental application Medifuge C.G.F & PRF devices creates Fibrin block matrix
Bruno Nicoletti
11/20/2013
Must have FDA approval, I agree not relevant if Dr Choukroun is owner Dr Choukroun is promoting better medicine than cow manure, I support 100% His PRF device vs Medifuge C.G.F.... you to decide
CLiff Leachman
11/21/2013
I have looked for it for years now. Lately I've spent an inordinate amount of time on the web searching and reading articles on the subject. Im spending evenings trying to dig up articles to see what is the superior centrifuge speed, temp, etc.
Cliff Leachman
4/24/2013
Would you be so kind asto reveal the g force, times and temperature? Thanx for the excellent work and for FREE! Please keep up the work!
CHOUKROUN Joseph
4/24/2013
Cliff, thanks for your comments. I cannot reveal nothing before the next week as I officially launch the A-PRF at the Osteology meeting in Monte-Carlo. Be sure that I'll do that soon. Take care about the courses without the PRF label education (my own label). They use PRF only for implants commercial advertizing. follow my eyes...
Cliff Leachman
4/24/2013
I will carefully follow your eyes...
Cliff leachman
4/25/2013
Here is an Excellent paper for PRP preparation. Optimized Preparation Method of Platelet-Concentrated Plasma and Noncoagulating Platelet-Derived Factor Concentrates: Maximization of Platelet Concentration and Removal of Fibrinogen Jun Araki, M.D.,1 Masahiro Jona, M.T.,2 Hitomi Eto, M.D.,1 Noriyuki Aoi, M.D.,1 Harunosuke Kato, M.D.,1 Hirotaka Suga, M.D.,1 Kentaro Doi, M.D.,1 Yutaka Yatomi, M.D.,2 and Kotaro Yoshimura, M.D. TISSUE ENGINEERING: Part C Volume 00, Number 00, 2011 ª Mary Ann Liebert, Inc. DOI: 10.1089/ten.tec.2011.0308
Bruno Nicoletti
11/19/2013
Simply purchase a Medifuge c.g.f. from Silfradent...... is cheaper It is possible to modify the rev/g protocol... but require high tech clever IT engineer
Bruno Nicoletti
11/19/2013
Medifuge c.g.f. is a phase separator Creates an injectable and/or a fibrin block matrix for placement with a layer of concentrated growth factor + CD34 positive stem cells with low cost sundries ie a PRP & PRF protocol...
Theresa Hamilton
12/10/2013
Would you recommend the same protocol for a patient that has RSD/CRPS?

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