Oral Bisphosphonates

Dr. Jeffries asks us:

I’m trying to get a barometer on the
prevailing opinion for dental implant placement on patients taking oral
bisphosphonates (Fosamax, Actonel, etc.)

I’ve placed them in a number of these
patients and have seen no problems, nor have I seen any published reports of
osteonecrosis associated with dental implant placement in these
patients.

What are some other surgeons’ philosophy when it comes to this
controversial topic?

4 Responses to Oral Bisphosphonates

1. Anonymous says:

   May 30, 2006 at 4:51 pm

   I personally believe there is no contraindication of performing routine oral surgery on someone who has been on Fosamax.

   Look at the numbers, 350 or so cases in over 45 million prescribed users… someone run the math but to me, its a chance that I will take after getting informed consent. It’s like saying the oral surgeons wont take out wisdom teeth because of possible nerve injury (1-4% complication rate).

   So, obviously there are certain guidelines that will help us clinicians to avoid ONJ prone cases such as age?, bone density?, length of Fosamax prescription?, and possibily co-morbidities which affect bone metabolism. The parameters of which I leave up to the clinical research colleagues who never get enough credit.
2. Robert J. Miller, DDS says:

   May 31, 2006 at 4:34 am

   Practicing in Florida, it seems that every post-menopausal woman is on a bisphosphonate. We routinely do implant procedures (all other factors being managed) and have never seen any of the post op complications being described. We do not dismiss this as a potential issue, but always get medical clearance for EVERY patient prior to surgery. Multiple significant medical problems WITH Fosamax would certainly give us pause.
3. dr talal says:

   May 31, 2006 at 11:30 am

   Risks for bisphophonate-induced exposed bone are related to: -the stereochemistry of the nitrogen side chain, -the cumulative bisphosphonate dose, -the duration of therapy,- the presence of medical and dental comorbidities,- the presence of pre-existing dental disease, and invasive dental procedures. -IV or per OS the risque exists Given that +it has a half-life of more than 10 years, +the current wide­spread use of Alendronate to prevent or treat early osteoporosis in relatively young women and+ the likelihood of long-term use as well as+ the ubiquitous presence of dental disease in our society gives us cause of concern.thats why prevention is the best treatment for onj and patients should be dispached to a dentist ,doing all the predisposed factors and than doing any surgery.
4. cjb says:

   September 13, 2006 at 6:40 pm

   I think it is time that the dental and medical communities
   join together for the common
   good of the patient… 75% of
   the world has some form of periodontal disease and the
   relation to cardiovascular, respiratory and birth is only
   growing stronger.. medical doc’s should refer all patients for for dental clearance prior to placing them on bis-meds..