Dental implant placement in patient taking methotrexate?

Last Updated: Nov 03, 2015

methtrexate I have a 50-year old patient suffering from arthritis for 20-years. She has been taking methotrexate for 20-years, initially IV, currently orally once a month. She is missing a mandibular first molar which she would like replaced with an implant. Radiographically bone looks sound. Are there any contraindications to me installing an implant in her first molar site?

6 Comments on Dental implant placement in patient taking methotrexate?

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Dr Bob

11/03/2015

Talk to the MD who is treating the patient. What does the bone density and occlusion look like?

Rand

11/03/2015

Methotrexate interferes with the growth of bone marrow cells.

Dr. Amer Al-Khazraji

11/04/2015

Methotrexate (MTX) is an anti-metabolite used in rheumatology and oncology. In high-dose MTX (30 mg/kg) impaired bone healing process.

Bob Mandell

11/17/2015

Last year, I had a patient who lost #9 due to a vertical fracture. After a literature search which found no credible studies concerning implant placement in Rheumatoid Arthritis Patients on Methotrexate. Following the extraction with 70/30 mix of allogenic bone grafting with a collagen membrane, and allowing for one year healing, Re-entry showed poor mineralization and bone formation. We decided to restore with a bridge instead.

12/14/2015

Would implant placement on people on methotrexate lead to failure?

Greg Kammeyer

10/07/2021

I've treated countless patients with implants on Methotrexate. Those that had healing problems typically had co-morbid factors.

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