Local Release of Bisphosphonates Improves Implant Stability


AddBIO AB, a subsidiary of Accelerator Nordic AB, has developed Zolidd®, a proprietary bioactive nanolayer for orthopedic and dental implants that releases bisphosphonate, a bone strengthening drug. A randomized clinical trial, conducted at Linköping University Hospital, Sweden, shows that dental implants with a bisphosphonate nanolayer have improved stability.

Millions of people worldwide have dental implants, i.e. screws inserted to support artificial teeth. The first time after surgery, the implant is often not stable enough to enable chewing. It may take several months for the bone around the implant to heal and become strong enough for the patient to regain normal chewing function.

“The study shows that local bisphosphonate improves implant stability, meaning that the time until normal chewing function could be shortened, thus reducing the suffering for the patient”, says Professor Per Aspenberg, Linköping University Hospital, co-founder of AddBIO.

2 Comments on Local Release of Bisphosphonates Improves Implant Stability

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Rodgeru
2/23/2012
Bisphosphonate mode of action is to suppress osteoclastic activity which would understandably lead to increased stability in the first year. My question is whether or not we want long-term bone holding our implants which no longer benefits from normal bone remodeling. Microfracture repair of bone in a stress-bearing implant improves stability over time. Loss of normal bone remodeling in the implant zone seems to be counter-productive. Noting the paradoxical femur fractures in osteoporosis patients on bisphosphonates, add in the drug's seven year half-life and project the impact this has on the implants over time.
Per Aspenberg
3/1/2012
Cancellous bone around bisphophonate-eluting implants IS remodelled, albeit somewhat more slowly. The effect here is mainly anticatabolic. See Wermelin et al. Bone. 2008 Feb;42(2):365-71

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