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Nanostructures Improve Bone Response

Last Updated: Jul 08, 2008

After 40 years of research and development, titanium is currently the most frequently used biomaterial in oral implantology, and titanium-based materials are often used to replace lost tissue in several parts of the body.

There are some alternatives to modulating the body’s response after implant placement. Modifying the implant surface topography has been a successful path among the scientific community, with the primary goals of achieving faster bone contact to the implant surface and more predictable results after several years. During the 86th General Session of the International Association for Dental Research, a team of Swedish researchers reported the results of experiments that focused on structures, so-called ‘nanostructures’, one million times smaller than a Canadian one-dollar coin. The results demonstrated enhanced bone response to dental implants modified with such small structures as soon as 4 weeks after implant placement.

Modifying the size and distribution of the nanostructures at the implant surface may not only represent a faster and more reliable treatment for patients, but also may help in understanding the sequence of events at the body-implant interface and provide guidelines for the further development of osseointegrated implant surfaces.

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Source: International Association for Dental Research

The International Association for Dental Research (IADR) is a non-profit organization with more than 10,800 individual members worldwide, dedicated to: (1) advancing research and increasing knowledge to improve oral health, (2) supporting the oral health research community, and (3) facilitating the communication and application of research findings for the improvement of oral health worldwide.

To learn more about the IADR, visit www.iadr.org.

This is a summary of an abstract entitled “Nano-size Structures and Enhanced Bone Formation”, by L. Meirelles et al., of the University of Göteborg, Sweden, to be presented at 12:00 noon on Thursday, July 3, 2008, in Room 713A of the Metro Toronto Convention Centre, Toronto, ON, Canada, during the 86th General Session of the International Association for Dental Research.

1 Comments on Nanostructures Improve Bone Response

Robert J. Miller

05/21/2010

Current research clearly shows that nanoimpregnated implant surfaces can significantly upregulate bone growth. Unlike plasma spray hydroxyapatite, calcium phosphate nanoimpregnation can help to skip the catabolic phase of bone and attract osteoblasts that directly start the process of bone bonding (by a factor of up to 500%). Rate of differentiation of stem cells into osteogenic lines, production of MAP kinases that are the building blocks of type I human collagen, and related bone enhancing proteins are dramatically increased. The best example of this is the Ossean surface from Intra-Lock. In both animal and human studies, nanoimpregnation clearly outshines all preceding alterations to the implant surface. RJM

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