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Does taking Sulfasalazine for arthritis affect socket healing using MinerOss?

Last Updated: Nov 25, 2014

am taking 1000mg Sulfasalazine daily for psoriatic arthritis. Will this have an adverse affect on bone formation within the extraction socket when the dentist uses MinerOss and guided tissue regeneration? Is there any danger of prion or viral infection from using MinerOss? I am also quite susceptible to cold sore breakouts following any significant facial trauma. I appreciate your consideration, and thank you in advance.

1 Comments on Does taking Sulfasalazine for arthritis affect socket healing using MinerOss?

Theodore M. Grossman DMD

11/25/2015

In Crohn's disease and ulcerative colitis, it is thought to be an antinflammatory drug that is essentially providing topical relief inside the intestine. It does this via a number of mechanisms such as reducing the synthesis of inflammatory mediators known as eicosanoids and inflammatory cytokines. However, unlike glucocorticoids (another class of drug used in the treatment in inflammatory bowel disease), sulfasalazine has no immunosuppressant action. When treatment for arthritis is successful, pain, joint swelling and stiffness will be reduced and this may slow down or stop the development of joint damage. The precise reasons why sulfasalazine are effective in various forms of arthritis is not clearly understood. Because sulfasalazine and its metabolite 5-ASA are poorly absorbed into the bloodstream, it is surprising that the drug is effective against symptoms outside of the intestine. One possible explanation is that, given that ulcerative colitis produces arthritic symptoms, the arthritic symptoms are actually a product of unrecognized ulcerative colitis, which is effectively treated with sulfazalazine. The other metabolite, sulfapyridine, is absorbed into the blood, and is believed to be the source of the side-effects discussed below. It is possible that the sulfapyridine is responsible for some of the anti-arthritic effects of sulfasalazine Regarding socket healing: It is poorly absorbed into the bloodstream, but it does reduce important inflammatory mediators needed for healing.

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