Bioactive glass graft to enhance autogenous grafts?

Bioactive glass graft has been used successfully in several clinical situations, including the treatment of oral bone defects. Upon implantation, bioactive glass forms a surface gel that traps cellular and noncellular materials within a gel matrix, which over time is transformed, remodeled, and replaced by newly formed osseous tissue.Bioactive glass also has been found to exhibit an antibacterial effect against subgingival and supragingival oral bacteria, and it may reduce implant-centered infections. 1 A recent study 2, compared the augmentation results in maxillary sinuses augmented with bioactive glass alone, bioactive glass combined with autogenous bone graft (1:1), or autogenous bone graft alone.

The conclusion:

The addition of 50% bioactive glass to autogenous bone graft improved the microarchitecture of the graft. Furthermore, the results for volumetric changes indicated that bioactive glass, its association with autogenous bone graft in a 1:1 ratio, and autogenous bone graft alone have similar resorption.2 Read More

A related study on Bioactive glass, 3, reported on two cases of radicular cysts where regular endodontic therapy was followed by surgical management with PRF and bioactive glass, and concluded that, ” the combination of PRF and bioactive glass is an effective modality of regenerative treatment for radicular cysts.” Read More

Are you using bioactive glass in your practice? What has been your experience with this material?

1.Anti-bacteria effects of particulate bioglass against sub-and supra-gingival bacteria. . Biomaterials
2001;22:1683e7. 2018 May/Jun;38(3):337-345. Allan I, Newman H, Wilson M.

2.Comparative study of volumetric changes and trabecular microarchitecture in human maxillary sinus bone augmentation with bioactive glass and autogenous bone graft: a prospective and randomized assessment.. Int J Oral Maxillofac Surg. 2018 May;47(5):665-671.Pereira RS.

3.Management of radicular cysts using platelet-rich fibrin and bioactive glass: a report of two cases.. J Formos Med Assoc. 2014 Jul;113(7):470-6. Zhao JH.

Unigraft is made of synthetic bioactive glass material, and offers an osteogenic framework for new bone growth and bolsters a higher level of osteoblastic activity to enhance bone regeneration. 15+ Years of successful clinical use in bone grafting applications. Learn More

One thought on “Bioactive glass graft to enhance autogenous grafts?

  1. WJ Starck DDS says:

    I wholeheartedly agree with the conclusions of this article. I’ve mixed 50% PerioGlas with 50% FDMB for years. The residual graft volume is amazing.

    It seems that the PerioGlas tends to resist flap contracture (and thus residual graft volume) while the FDBM is being revascularized and replaced.

    Try it you’ll like it!


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