Bone Regeneration with rhBMP-2?

Recombinant human bone morphogenetic protein type 2 (rhBMP-2) has been used as bone substitute for the reconstruction of large bone defects. Does adding a collagen-based biphasic calcium phosphate composite to recombinant human bone morphogenetic protein 2 (rhBMP-2) improve its regenerative capacity? A recent study 1 appears to suggest the affirmative. The investigation compared the bone regenerative effects of a recombinant human bone morphogenetic protein 2 (rhBMP-2)-loaded collagen-based biphasic calcium phosphate composite (BCPC) and rhBMP-2-loaded biphasic calcium phosphate (BCP).

The conclusion:

BCP- and BCPC-loaded rhBMP-2 significantly improved bone regeneration and BCPC led to a dense network of new bone and bone particles during the early healing period. BCPC can therefore be considered as a promising candidate for carrying rhBMP-2.

Are you using rhBMP-2 in your practice and in what capacity? Results?

Read the Full Abstract Here

1. Clin Oral Implants Res. 2016 Nov;27(11):e91-e99. Bone regenerative efficacy of biphasic calcium phosphate collagen composite as a carrier of rhBMP-2.
Lee EU, et al.

3 thoughts on “Bone Regeneration with rhBMP-2?

  1. Dr. Gerald Rudick says:

    rhBMP-2 is a very expensive proposition to the dentist and ultimately to the patient.

    To draw blood is not difficult, and learn from Drs. Joseph Choukroun of Nice France, Avi Chitri of Miami, Robert Miller of West Palm Beach, Adi Palti of Baden Baden Germany, Marius Stegman of Germany, Jim Rutkowski of Pensylvania,the Salama Brothers of Atlanta Georgia, Gerald Rudick of Montreal, etc……… the centrifuge is not expensive and separating Platelet Rich Fibrin is an easy thing to do……… will be using the patient’s own biological products, at almost no cost.

    We have been doing this for 15 years, and the results are excellent.

  2. Peter Fairbairn says:

    CaP materials have great Osteo-inductive potential in themselves so not really needed . The key is their ability for up-regulation of angiogenesis by effecting the endothelial cell growth factors …
    Herein lies the key ( Oxygenation ) to bone healing and regeneration ……but maybe an idea to not look in the low impact factor Dental journals but seek the answers in high impact medical research .


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