Bone Regeneration with rhBMP-2?

Recombinant human bone morphogenetic protein type 2 (rhBMP-2) has been used as bone substitute for the reconstruction of large bone defects. Does adding a collagen-based biphasic calcium phosphate composite to recombinant human bone morphogenetic protein 2 (rhBMP-2) improve its regenerative capacity? A recent study 1 appears to suggest the affirmative. The investigation compared the bone regenerative effects of a recombinant human bone morphogenetic protein 2 (rhBMP-2)-loaded collagen-based biphasic calcium phosphate composite (BCPC) and rhBMP-2-loaded biphasic calcium phosphate (BCP).

The conclusion:

BCP- and BCPC-loaded rhBMP-2 significantly improved bone regeneration and BCPC led to a dense network of new bone and bone particles during the early healing period. BCPC can therefore be considered as a promising candidate for carrying rhBMP-2.

Are you using rhBMP-2 in your practice and in what capacity? Results?

Read the Full Abstract Here

1. Clin Oral Implants Res. 2016 Nov;27(11):e91-e99. Bone regenerative efficacy of biphasic calcium phosphate collagen composite as a carrier of rhBMP-2.
Lee EU, et al.

3 thoughts on “Bone Regeneration with rhBMP-2?

  1. Dr. Gerald Rudick says:

    rhBMP-2 is a very expensive proposition to the dentist and ultimately to the patient.

    To draw blood is not difficult, and learn from Drs. Joseph Choukroun of Nice France, Avi Chitri of Miami, Robert Miller of West Palm Beach, Adi Palti of Baden Baden Germany, Marius Stegman of Germany, Jim Rutkowski of Pensylvania,the Salama Brothers of Atlanta Georgia, Gerald Rudick of Montreal, etc……… the centrifuge is not expensive and separating Platelet Rich Fibrin is an easy thing to do……… will be using the patient’s own biological products, at almost no cost.

    We have been doing this for 15 years, and the results are excellent.

  2. Peter Fairbairn says:

    CaP materials have great Osteo-inductive potential in themselves so not really needed . The key is their ability for up-regulation of angiogenesis by effecting the endothelial cell growth factors …
    Herein lies the key ( Oxygenation ) to bone healing and regeneration ……but maybe an idea to not look in the low impact factor Dental journals but seek the answers in high impact medical research .


Leave a Comment:

Comment Guidelines: Be Yourself. Be Respectful. Add Value. For more details, read our comment guidelines. Though we require an email to comment, we will NEVER publish your email.
Required fields are marked *

Posted in Implant News, Regenerative.
Bookmark Bone Regeneration with rhBMP-2?

Videos to Watch:

Maxillary Bone Reconstruction

This video demonstrations Maxillary Bone Reconstruction using Subnasal Floor Elevation and an Osteotome Closed Approach[...]

Watch Now!
Infection of Lower Premolar: Extract and Place Implant

In this video, the lower left 2nd premolar was extracted due to infection, and implants[...]

Watch Now!
Flapless Immediate Implant and Provisional

This video shows a technique showing using the patient's own tooth as a provisional at[...]

Watch Now!
Extraction and Immediate Implant with Luxator LX

Extraction of tooth #8, using Luxator LX, and then an immediate implant and provisional.[...]


Watch Now!
Dealing with the Implant Gap

This short video discusses how to best deal with the gap after immediate implant insertion[...]

1 Comment

Watch Now!
Lower Right Molar Extraction & Immediate Implant Placement Using i-PRF

In this video, the lower right second molar was extracted and grafted with i-PRF and[...]


Watch Now!
Maxillary Implantation with Treatment of Chronic Sinusitis

This video shows two cases where implants were placed following treatment of Sinusitis. [...]


Watch Now!
Suturing in Guided Bone Regeneration

This video provides clinical tips for suturing techniques in Guided Bone Regeneration. In Guided Bone[...]

1 Comment

Watch Now!
Socket grafting with Collagen Dressing and Bond Apatite

This video demonstrates socket grafting with just bond apatite and a collagen wound dressing.[...]

Watch Now!
Dental Implant for Lower Right Second Molar

This video shows implant placement on the lower right second molar.[...]

Watch Now!
Saving a Bridge with Periodontal Therapy

This video shows a case involving a 48-year-old male who was referred for periodontal treatment[...]

Watch Now!
Immediate Loading Full Arch

This video shows a case of Immediate loading of a full arch with simultaneous guided[...]

Watch Now!