Recombinant human bone morphogenetic protein type 2 (rhBMP-2) has been used as bone substitute for the reconstruction of large bone defects. Does adding a collagen-based biphasic calcium phosphate composite to recombinant human bone morphogenetic protein 2 (rhBMP-2) improve its regenerative capacity? A recent study 1 appears to suggest the affirmative. The investigation compared the bone regenerative effects of a recombinant human bone morphogenetic protein 2 (rhBMP-2)-loaded collagen-based biphasic calcium phosphate composite (BCPC) and rhBMP-2-loaded biphasic calcium phosphate (BCP).
BCP- and BCPC-loaded rhBMP-2 significantly improved bone regeneration and BCPC led to a dense network of new bone and bone particles during the early healing period. BCPC can therefore be considered as a promising candidate for carrying rhBMP-2.
Are you using rhBMP-2 in your practice and in what capacity? Results?
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1. Clin Oral Implants Res. 2016 Nov;27(11):e91-e99. Bone regenerative efficacy of biphasic calcium phosphate collagen composite as a carrier of rhBMP-2.
Lee EU, et al.