Dental implant surgery with multiple systemic disorders and oral bisphosphonates?

CC: A 65 years old female patient has consulted to our department for the treatment of her fractured dental implant.

HPI: Her first dental implant surgery was performed in 2015 when three dental implants were placed on the edentulous left mandibular posterior (4,6,7) region and right mandibular posterior (5,7) region. Her second dental implant surgery was performed on 2018, a flapless surgery performed with a surgical guide and 2 dental implants was placed in the right maxillary posterior region (4,6) with hyaluronic acid application on the dental implant and implant socket during the surgery .

PMHX/ Medications: The patient has a significant past medical history. For her hypertension, she takes Nebivolol (Vasoxen). She has an overactive bladder. She takes Lansoprazole for her chronic gastritis. She was also diagnosed with systemic lupus erythematosus and Sjögren’s disease and she is still using oral corticosteroids (methyl-prednisolone 4mg PO). She was diagnosed with osteopenia on 2009 and she used Risedronate (Actonel IV) for one year and then she continued with Ibandronic acid (Bonviva PO) for 9 years (once per month).

She is also taking SSRI (Cipralex 10 mg PO) and antipsychotic (Seroquel).

She was diagnosed with lichen planus on 2018 and using a topical medication.

What would you recommend for the replacement of the fractured dental implant?



12 Comments on Dental implant surgery with multiple systemic disorders and oral bisphosphonates?

New comments are currently closed for this post.
Peter Hunt
11/7/2019
This is a complex case that you have managed well over the years. It's unfortunate that this implant has fractured. While the baseline instinct might be to remove the apical portion that remains, this might be difficult and you are close to the nerve. Regenerating this region may also be complex, and might not result in an ideal site for a new implant. It might be worth considering leaving the apical portion of the implant in place , then placing a new implant more distally, where the pontic is at present, and then building a new bridge with a mesial cantilever in the first premolar region. Less invasive and perhaps more effective. Something to consider, good luck.
Emil
11/7/2019
Skip the broken implant site and/or remove it and graft and place new implants in the first premolar and current pontic site for a 3 unit bridge. There is a reason the implant broke ... no more cantilevers here. I would tend to look whether the root tip is easy to remove and remove it Safely if possible.
John Beckwith
11/7/2019
Any further surgery should be avoided. Remake the bridge on the lower left by telescoping the canine and connecting t the implants
Dr. Moe
11/7/2019
Hi, Other than the real issue at hand, the Patient is showing some calcification on Patient's left side (which is the right side of the picture) in 2018 Pano. Check that as well. Where are they? Carotid? Just thinking out loud.
Dr Dale Gerke, BDS, BScDe
11/7/2019
This is obviously a very complex case. You have not indicated your expertise so advice is a little difficult to give except to say that you should consider a multi-specialist treatment plan approach. Although leaving the apical section of the broken implant would be a convenient option, as best I can see there is implantitis around to remaining section which I suspect will lead to an acute flare up at some stage soon and/or I suspect it will be unlikely that the bone infection/inflammation response will resolve if it is left. However it should be removed by a very competent oral surgeon. Clearly there are medical considerations but from a dental point of view I think you need to answer these questions before any proper advice can be given: 1 what are the CTx scores in regards to her bisphosphonate medication 2 how bad is her oral lupus 3 how bad is her Sjögren’s disease – especially how viable is her saliva flow You will understand that placing more implants is an elective option and I doubt you can justify doing this if her CTx score is below 400 (I understand some colleagues braver than me will push this to around 150 - but I repeat can you justify this professionally if she suffers consequent ONJ). Oral lupus can have negative implications on longevity of any restorative work due to the problem of maintaining viable gingival/mucosa health around teeth and implants. So this needs to be considered in regards to implants and also her remaining dentition. Similarly Sjögren’s disease can have an enormous impact on longevity of teeth. So your consideration is not just whether implant placement is wise/possible but also what is the reasonable expectation for longevity of her remaining dentition. Unfortunately I expect that if she requires dentures in future, both lupus and Sjögren’s disease will make it very difficult for her to comfortably wear dentures. With all this in mind, my suggestion would be to aim at getting her CTx score above 400 because that will give you many more options. I would go very slowly in regards to any treatment plan but I would emphasise to her the importance of getting her natural dentition into a state of good health. It may be that she is orally fit and healthy but as best I can see there are some problems in at least the upper arch that should be sorted out. Most importantly the patient should be informed of the difficulty of maintaining her long term oral health and the consequences if she is non compliant. Once a stable, disease free base line is established, further extensive treatment can be considered dependent on: her compliance, her health, her finances and her wishes. So you may gather that my advice would be to proceed slowly and with caution. If you consider the current situation, as long as the problem involving the residual fractured implant is solved, and the cantilever bridge issue and caries and perio is treated conservatively, is there any reason to be heroic in regards to elective surgery? It seems to me that she can eat adequately, I suspect she has reasonable aesthetics, so why push the envelop too quickly and un-necessarily?
canbayrak
11/7/2019
Ctx score below or above 400 or 150, i am confused
Dr Dale Gerke, BDS, BScDe
11/8/2019
Bisphosphonate medication has been strongly associated with osteonecrosis of the jaw (ONJ). It seems to be a little less detrimental if medication is given orally (presumably due to lesser uptake). However further research suggests that CTx blood level scores can be measured and it has been reasonably well agreed in the literature that if the CTx score is above 400 then osseous surgery has minimal risk of ONJ. If the CTx score is below 150 there is a much larger risk of ONJ although some reports also include CTx levels of around 70-80 and below this there is extreme risk. However there is a grey area between 150 to 400 where there is not necessarily consensus about the risk of ONJ. Some literature says that, if absolutely necessary, osseous surgery can proceed with caution and with very conservative surgical technique if the levels are above 150, but the risk of ONJ is significant but not extreme. However other reports indicate that surgery is unwise unless the levels are above 400. Hence my comment that some colleagues might proceed to surgery if the scores are above 150, but I would wait until they are around 400. I am not sure of the literature reports on the time for CTx score to return to 400 after administration of bisphosphonates, but with the last 3 of my patients I found the levels increased about 10-15 points every month.
Dr. Moe
11/8/2019
Dr. Gerke, Thanks for the information. Greatly appreciate it. Knowing more about how to help our patients is always good. Thanks for the CTx break down. Sincerely,
Dr. Gerald Rudick
11/7/2019
As mentioned above, this is a complex case, and will become more complex if further surgeries are planned. By comparing the two panorexes over a three year span, it is obvious that this lady is a bruxer, and other implants are at risk to fracture. I would try to detoxify the fractured implant, place a collagen plug over it, and let the soft tissues close and keep it as is. I would remove the implant crowns on the existing lower implants and replace them with either ball attachments or locator type retainers, that would support a removable partial lower denture. Periodically, the lower partial denture teeth can be changed, and the occlusion opened to take the strain off the already worn down natural lower incisors...….with the type of medication that this patient is on, there is a risk of creating an osteoradionecrosis situation.
Richard Hughes
11/8/2019
The patient has a colorful medical Hx. Dr Beckwith has the fight approach.
czimbalmosdr
11/9/2019
I think the apical part does not worth to harm periosteum with a full thickness flap, because restriction of blood supply increases the chance of onj. If the gingiva is healed over the implant, I would go for hybrid anchorage. I would not touch the left posterior abutments, literature showed that detachment of abutments leads more gingival demolition. I would splint the implants with the canine for one year, and control clinical and radiographic signs. please update your case next year!
DIO Implant Shoreline
11/21/2019
The quality of dental implants matters a lot. When there is lack of dental implant quality, maintenance, precautions etc. it becomes easier that the dental implants get damaged. Thanks for sharing this story here. After reading this, more people will get updated. DIO Implant Shoreline

Featured Products

OsteoGen Bone Grafting Plug
Combines bone graft with a collagen plug to yield the easiest and most affordable way to clinically deliver bone graft for socket preservation.
CevOss Bovine Bone Graft
Make the switch to a better xenograft! High volume of interconnected pores promotes new bone. Substantially equivalent to BioOss and NuOss.