Platelet-rich fibrin (PRF) has been applied successfully in implant dentistry. How would a mixture of PRF and another graft material, compare to the graft material alone? A recent study 1, evaluated the effect of leukocyte and platelet-rich fibrin (L-PRF) in combination with deproteinized bovine bone mineral (DBBM) on bone regeneration in maxillary sinus augmentation.
There was no qualitative difference in histological analyses among the groups. In all samples, a newly formed bone was in direct contact with the residual material…Both techniques were effective for maxillary sinus augmentation, and after 6 months of healing, the addition of L-PRF in DBBM did not improve the amount of regenerated bone or the amount of the graft integrated into the newly formed bone under histological and histomorphometric evaluation.1 Read More
(Note: “L-PRF is a high density fibrin clot. It serves as a biological healing matrix by supporting cell migration and cytokine release, expanding the range of its potential applications greatly. When a graft material is suspended in the clot, the graft’s handeling characteristics are dramatically improved.”2)
If you use PRF (L-PRF) in your practice, how do you use it? In combination with another graft? What has been your clinical experience?
1.Maxillary sinus augmentation with leukocyte and platelet-rich fibrin and deproteinized bovine bone mineral: A split-mouth histological and histomorphometric study.. Clin Oral Implants Res. 2018 Jan;29(1):67-75. Nizam N et al.
2.L-PRF at Intra-Lock