Osteograf Low Density HA graft: Long delay for implant placement?

I am a general dentist with little implant experience. Recently I did a full mouth extraction and inserted immediate complete dentures for the maxilla and mandible. We planned on switching to implant retained overdentures after 3-4 months. The periodontist had requested that I place cadaver allograft bone following extraction for more rapid osteoinduction.  However, Osteograf LD [hydroxyapatite allograft] was placed instead due to a mix up. I was told that it may take a year before the patient can get implants now, which the patient is not happy with. I would like to hear about your experiences with Osteograf LD and implants? Is it true that my error in selection of graft material result in such a long delay in bone osteoinduction and regrowth?

18 Comments on Osteograf Low Density HA graft: Long delay for implant placement?

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CRS
12/25/2012
The big question is how much natural bone will fill in the spaces between the HA. Early sinus lifts were almost all HA (a la Dennis Tarnow) with implant placement. The patient will get a stable ridge for denture support and a locator retained prosthesis to take advantage of the stability of the HA which will never go away. We used this back in the day for ridge augmentation. What does your periodontist colleague suggest? Literature search? The prosthesis design is key, using the ridge stability of the HA as an advantage with an implant retained not supported denture vs a disadvantage. During the healing period the denture will be less likely to cause bone resorption a plus! This is where a team approach is also key, you are in charge of the treatment plan if handled appropriately you will have a very satisfied patient. At implant placement with the aid of a clear denture for reference I would core out the areas of implant placement and place autologous bone if I did not feel there was enough bleeding bone sort of a secondary graft, primary or secondary implant placement judgement call. Could you post a panorex to see how dense the HA is? If the implant placing surgeon is experience they hold be able to help, united front for the patient. If the ridges are great you may need very little implant retention . A film would help! All is not lost!! I actually had a case where I places allograft only and had a lot of bone resorption while the implants were integrating and wished I had used some Bio OSS since wearing the prosthesis may have contributed to the resorption. Sometimes a "mistake"cn have a positive outcome, I call them happy accidents!
CRS
12/25/2012
This product is resorbable but can take up to year, I don ' t like synthetics in my implant practice since I don't like the "feel " of the "bone" too grainy not much bleeding and poor lock in of the implant.I gave you the worse case scenario above with overly dense non-bleeding bone. Each practioner has their own preferences and I don't have your treatment plan for the final prosthesis so take my comments with a grain of salt or HA!
greg steiner
12/26/2012
CRS This product is not resorbable although the company may imply that it is. The Company states in its FDA filing that it is nonresorbable. If you question this you can check out the FDA 510K summary. This graft will be there forever. Greg
CRS
12/26/2012
Thank you Greg I was suspicious that it would resorb !
David Levitt
12/25/2012
It will depend on how heavily you condensed the HA. If there is no space for bone to grow between the particles then 1 year. If light condensation then 4months.
savoka77
12/25/2012
you may still have enough bone to place the implants in between the sockets and then no matter what happens to the allograft inside the sockets
Dr. Bill Woods
12/25/2012
Depending on what bone is available, I tend to think that not much was there for harvest. I use mineral used bank bone and have had good lunch with that, provided that I have had as much primary closure. I'm conservative, and I also think that when I'm out of this bone I am going to switch to corticocancellous bone. Protection of the graft sites is mandatory. No pressure. And I tend to wait a little longer. I haven't used mini's giraffes support though there is merit to that in my view. Look at your grafts on a pan or better yet a CBCT. See what you have. If it isn't enough, some simple bone spreading my be just fine for some of the sites and you can stagger placement times. One last thing- encourage your patient to remain patient for something expecting to last a long time. A few extra months isn't really a long wait for a reasonable person. JM2C. Hope that helps. Bill
Timothy Hacker DDS D-ABOI
12/25/2012
You are wise to seek help in this case. There is no replacement for experience. In this case you will be wise to consult with someone in your area who is experienced in placing implants and restoring implant retained overdentures. In most of these extraction cases alveloplasty is done during the extraction procedure. So, much of the bone you have grafted will probably need to be taken away anyway. (Alveloplasty gives you prosthetic clearance). Sinus augmentation procedures are done with Cadaver (Irradiated cancellous) bone so implants may be placed in the cuspid and premolar areas for proper prosthetic angulation. Not in the anterior. The palatal trajectory gives you improper implant angulation and inadequate clearance for an overdenture. You need to learn alveolar bone development procedures. Your implants will be much more stable and predictable long term in stable alveolar bone. Your mistake was not with the grafting of LD300. Your mistake is planning a procedure without adequate training. The periodontist has a point, but if you had training you would not even be asking the question about grafting materials. Oh, BTW, don't use synthetics in any graft that you intend to place an implant. It is not a wise choice. Some Drs say they get away with it, and companies sell the stuff with compelling promises. At the end of the day, synthetic particles do not direct bone growth in the proper shape for implant thread geometry. Get training and take care of your practice. You know your patients better than anyone else. The AAID is a good place to start.
dr. bob
12/25/2012
Extraction sites will heal with no grafting. If initial stability could be established using the remaining bone after the teeth were removed the implants could have been placed at the time of extraction. If there was enough bone to place the implants at the time of extraction then your graft should slow the loss of facial bone and allow wound closure. Provided that facial bone was intact after extractions you should be able to keep your schedule.. If the facial bone was lost or absent at the time of extraction there is some doubt that this grafting procedure will result in providing enough bone to place the implants even after a year of healing. Without pre-operative x-rays and knowing the quality of the post extraction bone I can not advise except for you to discuss the situation with your implant surgeon. May I ask why the implant surgeon did not extract and graft these sites?
Timothy Hacker DDS D-ABOI
12/25/2012
I agree with Dr. Bob. Combine exodontia and implant placement when ever possible. It is doubtful that your grafting is of any consequence.
CRS
12/26/2012
That is why the final prosthesis needs to be planned at the get-go. The alveoplasty for a conventional denture is more of a beveling and removal of rough edges. If an implant supported prosthesis is planned then height needs to be adjusted for the implants and bar. Locators don't need much reduction. The surgeon needs to know what the plan is.
greg steiner
12/26/2012
Dr. Hacker The poster did consult with an experienced clinician and formulated a treatment plan. I am sure you don't think that a general dentist is not capable of extractions and socket grafting and having the specialist place the implants. I respect your opinion but you advised alveloplasty to remove much of the grafted material. I am my years of regenerative therapy I have never ground down an arch for prosthetic clearance however I regularly open bites to regain an ideal facial profile. I suggest before you grind down another arch you examine the patient's facial profile to determine if they are overclosed. You say it is not wise to graft with synthetics. If you plan to use cadaver bone for eternity you must think that science is incapable of progress. The failures I see are implants placed in sockets with an allograft or xenograft which produces sclerotic bone that ultimately fails. When I see a site grafted with an allograft or xenograft I commonly advise the graft material be removed and replaced with a synthetic that will stimulate the production of natural bone and place the implant in 8 weeks. Most patients agree to my reasoning because they did not want cadaver bone or cow bone that will never be resorbed in the first place. Greg Steiner Steiner Laboratories
Timothy Hacker DDS D-ABOI
12/26/2012
Thanks for your comment Greg. I do believe that implant surgery and prosthetics will become mainstream general dentistry. Training and experience are the issues here. Synthetic bone grafting products have their place. However, I am not a fan of placing these grafts that are non-resorbable or resorb very slowly. As you have stated, some of these products are good osteoconductors, thus promoting chemotaxis and cytotaxis. I think you will agree that relying on a graft to support implant primary stability is asking for failure. I get the best results when I place implants in natural stable resident alveolar bone. If it is not available, I can develop it in several ways. Grafting for implant stability is not common place in my practice. I also agree with you that any alveloplasty is driven by the prosthetic end result. Some cases indicate it and others do not. There is no replacement for experience and training.
CRS
12/26/2012
Dental school will have to be longer than 4 years to teach oral surgery. It's not just about the exodontia and grafting it is about knowing how to manage a surgical patient, post op care, complications and medical issues. As a business model a generalist can be more productive doing what he is best at. A general practice mixing post operative oral surgery patients is a difficult business model. This experience does not simply come with an implant course or institute but with a hospital based residency, knowing how to truly manage these types of cases. I do agree that the final result does end in the hands of the individual practitioner (there are some pretty bad oral surgeons out there)and I personally learn many fine tips from my generalist referrers. I think the key is a colleaguel (sp?) approach since one does not know what they don't know.Respect for our colleagues is key. As for my practice I don't mix in exodontia with implant cases since they require different skill sets and things run smoother. We are not a one stop shop! As I do not place abutments but like a team approach! Thanks
greg steiner
12/26/2012
Dr. Hacker I very much agree. We are moving away from the amount of mineral content on the radiograph toward the amount of cellular vitality. Greg Steiner Steiner Laboratories
SAAD BOJI
12/26/2012
So the HA bone grafts are old one it is better to remove old graft and insert autologous graft ,to be sure that with HA graft you will never have more than 20-30% healed natural bone even after 8 years ,so do it as soon as possible ,before the patient get angry with you
greg steiner
12/26/2012
Dear Poster OsteoGraf LD 300 is non resorbable and it will be present forever. I can assure you that there will be no difference between 6 months and one year. With OsteoGraf LD 300 you will have normal bone between the graft particles. This is better that an allograft because in that case you only have sclerotic bone between the unresorbable cadaver particles and the bone will have little to no vascularity or osteoblasts in response to the foreign proteins contained in the cadaver bone. The body does its best to spit out the cadaver bone so the only time I will place an implant in a site grafted with an allograft or xenograft is when I can see that the body has been successful in expelling the majority of graft particles. In those cases I place the implant so it is at least partially in normal bone. It sounds like you are working with a skilled surgeon. I suggest that the implants be placed in 6 months and positioned interproximally where the implant will be primarily in natural bone. Oh by the way OsteoGraf LD is an alloplast (synthetic) not an allograft (cadaver). In addition cadaver bone is not osteoinductive. I think you intended to say osteogenic but allografts are not osteogenic either. Don't worry about the misuse of terms because if you were talking about composites I would have no idea what you are talking about. Greg Steiner Steiner Laboratories
Richard Hughes, DDS, FAAI
12/27/2012
Dense HA does not resorbe. Synthetics, such as OsterGen perform very well, as do other synthetics. If compounded with autogenous bone or PRP and one follows the eleven keys of bone grafting as presented by Misch, you will have success. As for grafting sockets, I do it. I don't want to lose a good site and I don't trust bone to always jump the gap. I've been disappointed several time, so I like to stack the odds in my favor. I've heard several clinicians that I respect, say they don't graft sockets. This is not a big bone of contention. Like I said above, I like to know that I will have a decent site for implant placement.

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